South Carolina Highway 265 (SC 265) is a 24.690-mile (39.735 km) primary state highway in the U.S. state of South Carolina.

It connects Jefferson with the cities of Kershaw and Chesterfield.

SC 265 is a two-lane rural highway that traverses 24.5 miles (39.4 km) from U.S. Route 601 (US 601) north of Kershaw to SC 9 near Ruby.

In 1940, it was extended southwest to SC 97 in Liberty Hill.

In 1951 or 1952, SC 265 was shortened to its current eastern terminus with US 601.