South Carolina Highway 153 (SC 153) is a 11.510-mile (18.524 km) state highway, providing a major connection between U.S. Route 123 (US 123) and Interstate 85 (I-85), and also serving as a primary commercial corridor for the suburban Greenville community of Powdersville.

The route travels generally in a southeast to northwest direction, starting unsigned on Brown Road in western Greenville County.

The two-lane road crosses over the Saluda River into Anderson County where it then meets I-85 at exit 40.

[5] Continuing north as a two-lane with turn median and flanked with a multi-use path, SC 153 ends at Saluda Dam Road.

[4] On December 8, 2020, SC 153 was extended 4.4 miles (7.1 km) north from US 123 to Saluda Dam Road (S-39-36).