Its southern terminus (eastern end) is at SC 346 about two miles (3.2 km) west of Catarrh.

SC 157 travels east along Marion Street through the eastern reaches of the town passing some houses.

It curves to due east and exits the town limits where it passes through a forest of pine trees.

The highway crosses the county line at the Little Lynches River where it continues east passing a few houses and churches whilst mostly in a wooded area with some rolling hills.

The northbound directions of the two truck routes travel along southbound US 601 forming a wrong-way concurrency.