SC 341 heads west along East Broadway Street through the town's business district.

At a railroad crossing, the road name changes to West Broadway and continues past additional businesses.

Before entering Lake City, SC 341 passes in front of some commercial and industrial warehouses.

Upon entering Lake City, SC 341 travels through it on Main Street, first through a residential neighborhood with an elementary school located along it.

Within the town, the road passes in front of many houses, some small businesses, a library, and a school.

It continues northwest along Lynchburg Highway through farmland and intersects US 401 about 1+1⁄2 miles (2.4 km) northeast of Elliott.

[6] Now approaching the city of Bishopville, the highway passes in front of Lee Central High School and has an interchange with I-20 at exit 120.

Upon entering the city of Bishopville, it takes the name of East Church Street where it heads through a residential neighborhood then transitions to the business district.

Outside the city limits, SC 341 breaks off the US 15/SC 34 concurrency and heads north-northwest through farmland and woods on Bethune Highway.

The highway heads into the center of town where SC 341 ends at Hampton Street which carries US 521 Bus./US 601 Bus.

The northbound directions of the two truck routes travel along southbound US 601 forming a wrong-way concurrency.