South Carolina Highway 164 (SC 164) is a 2.500-mile-long (4.023 km) state highway in the U.S. state of South Carolina.

SC 164 begins at an intersection with SC 174 west-southwest of Hollywood, within Charleston County, where the roadway continues as Willtown Road.

It travels to the northeast as a two-lane road with a 55 miles per hour (89 km/h) speed limit.

It enters the city limits of Hollywood.

[2] The entire route is in Charleston County.