South Carolina Highway 172 (SC 172) is a nine-point-zero-zero-zero-mile-long (14.484 km) state highway in the U.S. state of South Carolina.

The highway travels through rural areas of Orangeburg and Calhoun counties.

SC 172 begins at an intersection with U.S. Route 178 (US 178; North Road) east-northeast of North, within Orangeburg County.

Approximately 1,000 feet (300 m) later, it meets the eastern terminus of SC 692, with SC 172 heading to the east-northeast before it enters Calhoun County.

It passes by the Do-Little Field airport just before it meets US 21 (Columbia Road).