South Carolina Highway 212 (SC 212) is a 5.670-mile (9.125 km) primary state highway in the U.S. state of South Carolina.

It serves the town of Williams by connecting it with nearby highways.

Within Williams, it intersects SC 362 at its eastern terminus.

[2] Established around 1938 as a new primary routing as a spur from US 21 to Williams.

In 1940, it was extended south to its current southern terminus at SC 64.