South Carolina Highway 254 (SC 254) is a 8.230-mile-long (13.245 km) state highway in the U.S. state of South Carolina.

It travels to the north and immediately curves to the north-northwest.

It has an intersection with U.S. Route 25 (US 25), US 178, and SC 72 and a crossing of Rocky Creek just before leaving the city limits.

Just before crossing Coronaca Creek, the highway begins to curve to the northwest.

Approximately 2,000 feet (610 m) later, it meets its northern terminus, an intersection with US 25.