SC 260 begins just north of the Santee Dam (which lies at the eastern end of Lake Marion) at a locale known as Eagle Point, within Clarendon County.

It then passes the Clarendon County Airport – Sprott Field, which is just east of the Wyboo Golf Club.

The highway crosses over Ox Swamp and Hog Branch just before entering Manning.

In the city, it passes Clarendon Memorial Hospital, then has an intersection with U.S. Route 301 (US 301; Sunset Drive).

About three blocks later, it meets its northern terminus, an intersection with SC 261 (West Boyce Street).