South Carolina Highway 268 (SC 268) is a 5.630-mile-long (9.061 km) state highway in the U.S. state of South Carolina.

The highway connects rural areas of Chesterfield County with Mount Croghan.

SC 268 begins at an intersection with SC 265 at a point southwest of Ruby, within a rural part of Chesterfield County.

It travels to the northeast and crosses Little Black Creek.

It continues in a fairly northeastern direction and crosses Deep Creek just before entering the city limits of Mount Croghan.