South Carolina Highway 269 (SC 269) is a 11.950-mile (19.232 km) state highway in the U.S. state of South Carolina.

The highway travels through rural areas of Richland and Fairfield counties.

It travels to the north and curves to the north-northwest and enters Fairfield County.

It curves to the north-northeast and the northeast and passes the Fairfield County Airport.

A short distance later, it meets its northern terminus, an intersection with U.S. Route 321 (US 321) at a point south of Winnsboro Mills.