South Carolina Highway 291 (SC 291), locally known as Pleasantburg Drive, is a 11.400-mile (18.347 km) state highway in the western part of the U.S. state of South Carolina.

At an interchange with US 276 (Laurens Road), the road becomes North Pleasantburg Drive, continuing north, passing the Greenville Downtown Airport and the Carolina First Center to the east via Tower Drive.

It continues through more commercial development before making a turn west to South Carolina Highway 253 at Paris Mountain Road.

[4] This included the establishment of McAlister Square in 1968 which closed in the early 2000s and is part of the University Center of Greenville.

[8] A revitalization plan for the Pleasantburg Drive area began in 1997 and a report was issued seven years later.