South Carolina Highway 253 (SC 253) is a 19.656-mile (31.633 km) primary state highway in the U.S. state of South Carolina.

The highway begins at SC 124 near Parker and travels 1⁄2 mi (0.80 km) northeast to SC 183 as West Blue Ridge Drive.

It then moves up to Sulphur Springs Road where the road changes to East Blue Ridge Drive before intersecting at Poinsett Highway on U.S. Highway 276 (US 276) before running concurrently on SC 291 as North Pleasantburg Drive for 0.16 mi (0.26 km) before turning left at Paris Mountain Road.

After traveling 2.53 mi (4.07 km) and passing Greenvista Drive, SC 253 becomes East Mountain Creek Road and traveling and additional 6.71 mi (10.80 km) before intersecting with SC 290.

[2][3] SC 253 started in 1939 at the intersection of US 25 and US 276 to form an 11 mi (18 km) highway around Paris Mountain State Park, ending around Travelers Rest.