South Carolina Highway 327 (SC 327) is a 22.623-mile (36.408 km) primary state highway in the U.S. state of South Carolina.

It serves as an alternative bypass east of Florence and a connector route from Interstate 95 (I-95) to Myrtle Beach.

SC 327 has two identities: one as a rural two-lane highway bypassing Florence and the other as a divided four-lane highway connecting beach travelers from U.S. Route 76 (US 76) and US 301 and onto Myrtle Beach to I-95.

In 1947 or 1948, SC 327 was extended east as a new primary routing from Evergreen to US 76/US 301 in Winona.

[6] In 2010, funds were appropriated to improve the interchange at I-95; construction began the following year.