South Carolina Highway 333 (SC 333) is a 3.340-mile (5.375 km) primary state highway in the U.S. state of South Carolina.

It serves as a connector highway between the towns of Scotia and Furman.

SC 333 is a two-lane rural highway that connects U.S. Route 321 (US 321) and US 601.

The first SC 333 did extend from its routing in 1940 west to Shirley then southeast to Garnett.

In 1941 or 1942, it was extended east to end at SC 631, west of Grays; creating a total of over 23 miles (37 km) in length.