It crosses over Willow Swamp and some railroad tracks before it intersects U.S. Route 321 (US 321; Savannah Highway) and the western terminus of SC 400 (Norway Road).

It travels in a roughly southeastern direction to an intersection with SC 70 (Binnicker Bridge Road).

Just before entering Cope, it crosses over Sam Branch and some railroad tracks and curves to the northeast.

In town, at the intersection with Slab Landing Road, the highway turns right to the south-southeast.

It curves to the southeast just before meeting its eastern terminus, an intersection with US 301/US 601 (Bamberg Highway).