South Carolina Highway 37 (SC 37) is a 15.430-mile (24.832 km) primary state highway in the U.S. state of South Carolina.

SC 37 is an original state highway, established in 1922.

In 1923, SC 37 was rerouted to Elko, leaving behind Williston Way (S-6-113).

By 1946, the two sections were combined, reaching its apex of nearly 40 miles (64 km) long.

The entire highway is in Barnwell County.