The highway connects the southern part of Cayce and West Columbia.

SC 35 begins at an interchange with Interstate 77 (I-77) in the southern part of Cayce.

It crosses over Congaree Creek on an unnamed bridge and passes the Cyril B. Busbee Middle School.

A few blocks after an intersection with U.S. Route 21 (US 21)/US 176/US 321 (Knox Abbot Drive), the highway leaves Cayce and enters West Columbia.

Approximately 1,500 feet (460 m) later, it meets its northern terminus, an intersection with US 378 (Sunset Boulevard).