The highway connects rural areas of Aiken and Saluda counties with Ridge Spring.

SC 392 begins at an intersection with U.S. Route 1 (US 1; Columbia Highway) south-southeast of Ridge Spring, Aiken County.

This intersection is southwest of Aiken Wayside Park.

It crosses Flat Rock Creek and passes by Flat Rock Cemetery just before entering the city limits of Ridge Spring.

At Main Street, it meets its northern terminus, an intersection with SC 23/SC 39.