South Carolina Highway 310 (SC 310) is an 8.500-mile (13.679 km) long state highway in the southeastern part of the U.S. state of South Carolina.

The highway travels in a south-north orientation from Holly Hill north to Vance, and then northwest to its northern terminus, completely within Orangeburg County.

SC 310 begins at an intersection with US 176/SC 453 Truck in Holly Hill.

After leaving Vance, SC 310 heads northwest and meets its northern terminus, an intersection with SC 6, just northwest of the city.

[2] SC 310 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.