The highway connects the Lynchburg area with Turbeville, via Shiloh.

It travels on a fairly southern direction, enters Sumter County, and has an intersection with SC 53.

The highways travel concurrently to the east and have an interchange with Interstate 95 (I-95) on the northwestern edge of Shiloh.

Upon leaving the city limits of Shiloh, the highway enters Clarendon County.

There, it meets its eastern terminus, and intersection with U.S. Route 301 (US 301)/US 378 (Main Street).