South Carolina Highway 60 (SC 60) is a 5.160-mile (8.304 km) primary state highway in the U.S. state of South Carolina.

It serves the town of Irmo, connecting nearby Lake Murray and Harbison State Forest.

SC 60 is a mostly four-lane with median suburban highway that travels 5.16 miles (8.30 km) from SC 6 to U.S. Route 176 (US 176), with an interchange with Interstate 26 (I-26)/US 76.

[3] SC 60 was established in 1929 as a new primary routing.

The route has remained unchanged since inception, though its eastern endpoint was originally US 76/SC 2; the highway was widened to mostly four lanes with median by 2000.