The highway connects rural areas of Newberry County with Pomaria.

SC 773 begins at an intersection with U.S. Route 76 (US 76) at a point east-northeast of Prosperity, Newberry County, where the roadway continues as a local road.

It travels to the northeast and crosses over various sets of railroad tracks.

It travels along the western edge of the Mid Carolina Club golf course just before an interchange with Interstate 26 (I-26).

SC 773 passes St. Paul's Cemetery before entering Pomaria.