Space Quest V: Roger Wilco – The Next Mutation is a graphic adventure game, created by Dynamix, and released by Sierra On-Line for MS-DOS on February 5, 1993.

The game was welcomed by critics as a fun addition to the series, although did not feature a voice-cast version as with Space Quest IV.

In the story, players assume the role of Roger Wilco, who, since the events of Space Quest IV, has applied to become a captain to fulfill a lifelong dream, while in the background an investigation is launched in to a spate of toxic dumping in the galaxy that is feared to be causing trouble.

Following the events of Space Quest IV, lowly janitor Roger Wilco applies for a place at Starcon Academy, hoping to become a captain on his own ship.

Meanwhile, Roger successfully achieves his dream, and is given command of his own ship, the garbage scow SCS Eureka (which looks and functions like an oversized vacuum cleaner).

After collecting rubbish in orbit over a jungle planet, the Eureka comes under attack by a homicidal gynoid named WD40, sent by the same company that came after him in Space Quest III.

Similar to Space Quest 4, there is a puzzle based around the copy protection system where an undocumented code needs to be discovered via in-game exploration.

According to Sierra On-Line, combined sales of the Space Quest series surpassed 1.2 million units by the end of March 1996.

He praised the "first-rate" graphics and sound, and described the dialogue and narration as "written with a dry wit and a sense of character that makes them a pleasure to read".