The Spercheios (Greek: Σπερχειός, Sperkheiós), also known as the Spercheus from its Latin name, is a river in Phthiotis in central Greece.

In AD 997, its valley was the site of the Battle of Spercheios, which ended Bulgarian incursions into the Byzantine Empire.

[3] The river begins in the Tymfristos mountains on the border with Evrytania and flows to the east through the village Agios Georgios Tymfristou, entering a wide plain.

[4] Its silt has slowly filled the Malian Gulf, turning Thermopylae from a narrow pass into a wide plain.

Antoninus Liberalis notes the tradition that Cerambus was punished for claiming that the nymphs of Mount Othrys, the Spercheides, were the daughters of Spercheios by the naiad Deino.