3VZB, 3VZC, 3VZD, 4L02, 4V24887720698ENSG00000176170ENSMUSG00000061878Q9NYA1Q8CI15NM_001142601NM_001142602NM_021972NM_182965NM_001355139NM_001372484NM_001372485NM_001372486NM_001372487NM_001372488NM_001372489NP_001136073NP_001136074NP_068807NP_892010NP_001342068NP_001359414NP_001359415NP_001359416NP_001359417NP_001359418Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.

SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of phospholipase D (PLD).

Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1.

Competitive inhibitors of SPHK block formation of S1P and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.

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