Spiro is a given name among Greek-speaking populations, Albanians, and the Christians of Lebanon.
As a Greek name, Spiro may also be spelled Spyro.
Spiros/Spyros is a male given name fairly common in Greek-speaking population (in Greece, especially in Corfu, whose patron saint is Saint Spyridon, in Cyprus and among the Greek diaspora) as well as among the Christians of Lebanon where it is a common first and last name.
The Greek diminutives for Spirydon are Pipis (Πίπης) and Pipeto (Πιπέτο).
It is one of a number of Jewish surnames that originated this way, along with the better-known Shapiro.