[4] Spirotetramat is active against piercing-sucking insects, such as aphids, mites, and white flies, by acting as an ACC inhibitor, interrupting lipid biosynthesis in the insects, and is in IRAC group 23.

[5] In plants, it is hydrolyzed to the enol form by cleavage of the central ethoxycarbonyl group.

Bayer obtained spirotetramat's first regulatory approval in Tunisia in 2007.

[8] Spirotetramat has moderate to low acute toxicity, is irritating to eyes and potentially sensitizing to skin.

[9] In Denmark, it is listed as harmful to aquatic invertebrates, but not dangerous to bees.