The St. Ann Cathedral[1] (also Caicó Cathedral; Portuguese: Catedral Sant’Ana) is a Catholic church located in the Monseñor Walfredo Gurgel Square in the center of the city of Caicó, Rio Grande do Norte State, in southern Brazil.

[2] Its construction began symbolically on July 16, 1748,[3] when the parish of Santa Ana was installed.

The cathedral of Santa Ana has a harmonious combination of Romanesque, Gothic and colonial styles.

By 1785 the Mother Church of Sant'Ana was built and the faithful could attend religious events.

Its conclusion would take place during the administration of the parish priest Francisco de Brito Guerra (1802–1845).