The Church of St. Anthony is a Roman Catholic parish church under the authority of the Roman Catholic Archdiocese of New York, located at 1496 Commonwealth Avenue, Van Nest, Bronx, New York City, near the corner of Mansion Street and Commonwealth Avenue.

St. Anthony's was founded shortly after the IRT elevated train line was extended into a part of the Bronx undergoing development.

[1] At the beginning of the Great Depression, the Stratton Flats development opened nearby which brought in a large group of Irish-Americans to the Parish.

Our Lady of Grace, on Bronxwood Avenue, was founded as an Italian personal parish in 1924 by Father Victor Bassi.

Bassi held Masses in two rented stores on White Plains Road until the first church building was dedicated on October 11, 1925.

The statue of Mary and Jesus in front of the church was sculpted by Sister Angelica Ballan, and was originally outside Misericordia Hospital on East 233rd Street.