St. Clairsville is a borough in Bedford County, Pennsylvania, United States.

[2] St. Clairsville was named after Major-General Arthur St. Clair, Revolutionary War veteran and Northwest Territory governor.

US-220's former alignment, Pennsylvania Route 869, passes just to the west of St. Clairsville, leading south to I-99's Exit 7 and north 1.0 mile (1.6 km) to Osterburg.

According to the United States Census Bureau, St. Clairsville has a total area of 0.03 square miles (0.08 km2), all land.

27.8% of all households were made up of individuals, and 16.7% had someone living alone who was 65 years of age or older.