The Church of St Gregory the Great is a Roman Catholic parish located on the Upper West Side of Manhattan, New York City.

Plans for a separate church were abandoned and renovations to the structure began in 1918 and the unused fourth floor was converted into a rectory; also installed were an elevator, a sky-lit gallery and later a library and roof garden with fish pond.

During the two year pastorate of Father Henry J. Browne, the church increased as a center of activism on behalf of the working class and opposition to the Vietnam war.

Philip F. Berrigan, S.S.J., (1923–2002), wanted by the FBI for destroying draft files and failing to surrender for his prison term, arrived at St. Gregory's to address a peace rally.

[6] The St. Gregory the Great building is a four-story structure, designed by Elliott Lynch as a parish school with the church occupying the ground floor.

The charming temporary-turned-permanent appeal includes painted timber wainscoting, a number of mosaic portraits and some substantial stained glass windows.

The choice of saints seems to reflect three influences: the predominance of Irish, French and German ancestry among the parishioners; the interest in those recently canonized or beatified during the time this art work was done (approximately 1920-1945); the gratitude of the parish toward the Order of the Visitation and its affiliate, the Sisters of Charity, who staffed St. Gregory's School until 1943.”[7] St. Gregory's runs a soup kitchen with nearby Advent Lutheran in that church's basement.