[2] By the mid-twentieth century, the Irish, Italian, Polish and other Europeans who lived in the area made way for a new group of residents who were mostly Latino (from Puerto Rico and immigrants from the Dominican Republic), as well as African Americans.

'"[3] Anthrax victim Kathy T. Nguyen had her funeral at St. John Chrysostom Roman Catholic Church on November 5, 2001.

“Nguyen, a native of Vietnam, died of inhalation anthrax in New York on October 31.”[4] Also, the funeral of NYPD Officer Daniel Enchautegui of the 40th Precinct in the South Bronx was held in this church, presided over by Cardinal Edward M. Egan.

The double-height-over-sunken-basement brick twin-towered church with stone trim was built at 985 East 167th Street and Hoe Avenue in 1900.

The church front elevation is symmetrically divided into three parts and consists of a nave with six-bay clerestory flanked to both sides by six-bay lean-to aisles, which terminate in the bookended square-in-plan single-bay four-stage towers, projecting a bay in depth to flank the gabled three-bay façade of the nave.

The central gabled façade has three equal round-headed entrance openings addressed by a flight of stone steps spanning between the towers.

Main façade is detailed with central three-bay breakfront that to ground floor is accentuated in four-centre-arched stone entrances.