St. Joseph's Catholic Mission at Bayou Derbonne is a historic Catholic mission founded in the 1800s along the banks of Bayou Derbonne near Montrose and Isle Brevelle in Natchitoches Parish, Louisiana, serving the Montrose and Cloutierville Creole community.

It was the cultural and religious center of the area's Louisiana Creole people, predominantly of French descent.

[1] The remnants of the church and cemetery are located on Highway 493 on the banks of Bayou Derbonne near the Cane River Waterway Commission.

The chapel was founded by French Creole families in the 1800s as a mission of St. Augustine Catholic Parish Church of Isle Brevelle.

[2] Notable Creole founding and patron families include Rachal, Longlois, Lacaze, Metoyer and Brevelle.