The school was established by Mother Camilla Madden, founder of the Adrian Dominican Sisters, on September 8, 1896, "to provide education to girls from families of moderate or poor financial circumstances".
[2] As early as 1892, plans were made to renovate a nearby house called Elm House for the remaining long-term hospital residents, but the Bishop of Detroit, John Samuel Foley, initially rejected the proposal to establish a school, asserting that the educational needs of the region were already met by the existing Saint Mary Academy in Monroe, Michigan,[3]: 130 which later became part of St. Mary Catholic Central High School.
After rejecting the proposed new school several more times, Foley finally relented to a provisional effort after visiting Adrian to preside over the induction of new sisters on November 18, 1895.
[3]: 235 The school succeeded in both reviving the solvency of the order, and providing an influx of new members, with a proportion of students choosing to join as nuns.
[8] Chemist Miriam Michael Stimson was a noted alumnus of the school who remained as a member of the order, and later taught at Siena Heights University.