[3] St. Mary's Hospital Medical Center was created in 1903 by the Congregation of the Sisters of Misericorde.

[4] The original hospital building was located in downtown Green Bay.

In 1960, Bishop Stanislaus Vincent Bona of the Diocese of Green Bay requested the sisters move their hospital to the west side of Green Bay, which was completed later that year, becoming the first and only hospital on the west side.

[4] In 2010, the hospital opened a new regional cancer center.

[6] The hospital also partners with the Medical College of Wisconsin's Green Bay campus to provide clinical rotations for medical students.