When it opened, Aquinas enrolled both male and female students, but was a single-sex educational institution, as boys and girls attended classes within separate wings of the school.

Other sports, such as soccer (boys and girls), baseball, softball, and swimming have also seen regional and state qualifiers over the years.

In 1984, STA won the Ohio State Championship in football in Division IV with a 23-0 win over Columbus Bishop Hartley Hawks.

Over a 2-year stretch, the 1984-1985 seasons, STA football compiled a total record of 25-1-1 with 2 state title game appearances and numerous all-Ohio selections.

In 2013 they were also sectional and district winners STA joined the North Coast League (NCL) beginning in the 2013-14 school year for all sports except football.