St. La Salle Hall is an H-shaped four-story academic building built in the Neoclassical style in the Philippines.

Originally built as a three-story structure, a fourth level was added in the 1990s for the residence of the De La Salle Brothers.

[6] Meanwhile, the second floor of the St. La Salle Hall houses the School of Economics and the Chapel of the Most Blessed Sacrament.

"[9] It is the only Philippine structure featured in the book 1001 Buildings You Must See Before You Die: The World’s Architectural Masterpieces, published by Quintessence Editions Ltd. in 2007.

[3] Due to the lack of space in the campus at Paco, the transfer of De La Salle College to Taft Avenue was decided.

The reason for the selection of the site was the close proximity of St. Scholastica's College, a girls' school located about 200 meters (660 ft) from the new campus.

Another reason for the selection was its close location to a streetcar station of the Manila Electric Railroad And Light Company allowing quick transport for the students.

Opposition to constructing the college at the new site came from certain American parties who had financial stakes in the properties that were supposed to be developed under the municipal planning scheme for the area.

On the same day, the Paco site was sold under the condition that the school is allowed to continue operation for 18 months before completely moving to the Taft campus.