Originally a town, it was annexed to Brno in 1850, and since November 24, 1990 it has been part of the city district of Brno-střed.

Apart from parts of the modern cadastral territory, most of Pisárky and about a third of Štýřice belonged to it.

Among the most important streets in Staré Brno are Poříčí, Nové Sady, Hybešova, Pekařská, Křížová, Úvoz, Hlinky and Veletržní.

The St. Anna hospital, the Masaryk Oncology Institute and the Starobrno brewery are located here.

Staré Brno borders the cadastral territories of Stránice to the northwest, Brno-město to the northeast, Trnitá to the east, Štýřice to the south, and Pisárky to the west.