The current district consisted of the territory of several villages, which were annexed to Brno in 1850, and is now has a highly urban character.

In the years 1854–1856, Rosické nádraží ('Rosice railway station') was built at the southern end of Trnitá Street, from which a link to the main station was built in 1868–1870, along a high embankment (only a small part of it has been preserved due to the recent construction of the Vaňkovka shopping center) .

In 1900, for a change, the Trnitá cadastral territory was slightly reduced in favor of Komárov north of Jeneweinova street, when the border here was moved to the bed of the Svitavský náhon (Svitava mill race).

[3] Trnitá borders Staré Brno in the west, Brno-město in the northwest, Zábrdovice in the north, Židenice and Černovice in the east, Komárov in the south, and Štyřice in the southwest.

Trnitá's entire residential development fell into disrepair during socialism and was demolished during the 1990s and after 2000, has a distinctly urban character, marked by the development of industry in the past, and above all in the times of communism by the insensitive construction of roads, and by neglecting the maintenance and repair of houses.

Important traffic arteries are Opuštená, Zvonařka, Úzká, Plotní, Dornych, Koliště and Křenová streets.