Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1.

Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription.

The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.

[11] SREBP-1c regulates genes required for glucose metabolism and fatty acid and lipid production and its expression is induced by insulin.

[16][17] SREBF1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.