[1] Evidence of benefit is lacking for long-term effects on weight loss and heart disease risks.

[2] Stevioside is the main sweetener (along with rebaudioside A) found in the leaves of Stevia rebaudiana, a plant originating in South America.

Dried leaves, as well as aqueous extracts, have been used for decades as a sweetener in many countries, notably in Latin America and Asia (Japan, China).

[3] The sweetening power of stevioside was estimated to be about 300 times stronger than cane sugar.

[3] Since 2008, the U.S. Food and Drug Administration has not objected to the use of stevia extracts and some purified steviosides, mainly stevioside and rebaudioside, as GRAS for use as an ingredient in manufactured foods.