[5][6] Along with Angomonas deanei, S. culicis is researched as model organism for the evolution of symbiotic relationsships with intracellular bacteria.

Eventually, by microbiological analysis of endosymbiont harboring Trypanosoma, this species was assigned to the genus Strigomonas in 2011, bearing the current name S.

It migrates from the mosquito midgut and enter the body cavity (haemocoel) and finally reside in the salivary glands.

[10] Unlike other trypanosomatids, S. culicis does not produce some amino acids such as methionine, histidine, and arginine; and vitamins such as thiamin, nicotinamide, and riboflavin.

[11] It acts as a cell organelle not only by supplying essential enzymes, but also by replacing paraflagellar rod associated to the axoneme, thus, intimately associated with the kinetoplast.