Sulphide Creek is a 2.5-mile (4.0 km) glacial tributary of the Baker River in Whatcom County in the U.S. state of Washington, draining a steep and narrow canyon on the southeast flank of Mount Shuksan, inside North Cascades National Park.

During the 1950s molybdenite (molybdenum disulfide) was prospected near the headwaters of the North Fork of Sulphide Creek, although the deposit was described as having "no economic value".

[4] Meltwater from the Sulphide and Crystal glaciers skips several hundred feet down a series of Shuksan greenschist cliffs into Sulphide Lake, a small and nearly inaccessible tarn at 3,800 feet (1,200 m) on the southeast flank of Mount Shuksan.

Sulphide Creek flows out of the lake and drops down a narrow, deeply incised rock chute forming Sulphide Creek Falls, one of the tallest waterfalls in North America with an estimated height of 2,182 feet (665 m).

[6] At the base of Sulphide Creek Falls, an unnamed tributary (which forms a high waterfall of its own) joins from the west.