The backup strip featured Thor reprints, from Journey into Mystery, including some of the Tales of Asgard.

The first issue also promoted the UK branch of Marvel's new in-house fan club, FOOM.

The book also changed orientation to become a landscape-format comic, following the lead of another relatively new Marvel UK title, The Titans.

It soon, however, continued The Super-Heroes comic’s tradition of rotating less-popular characters like Doctor Strange, Tales of Asgard, and Moon Knight; before settling with The Invaders.

In late 1976, the Spider-Man weekly comic absorbed another cancelled Marvel UK title into its pages: The Titans.

Following the precedent of the earlier merger with The Super-Heroes, with issue #199 the book changed its title again, to Super Spider-Man and the Titans.

The book continued using the landscape orientation until the penultimate edition of Super Spider-Man and the Titans (#229), when it reverted to the traditional "portrait" format — just in time for the next merger.

In 1976 Marvel UK had debuted its first original weekly series, starring the British superhero Captain Britain.

In 1978, British editor Dez Skinn was hired by Stan Lee to take over the now ailing Marvel UK.

Although original US artwork was reprinted, as in previous publications, panels were often chopped up, re-arranged, removed or reduced in size to both meet the lower page count and look more like existing British comics.

In addition to Spider-Man, the title featured five backup strips, starring the Fantastic Four, the Avengers, Thor, the Sub-Mariner, and Nova.

Backup stories featured the two main characters' female counterparts, Spider-Woman and She-Hulk, as well as The Defenders (which was continued from Hulk Comic).

The 1977–1979 The Amazing Spider-Man live-action television series inspired yet another title change, in October 1981; the Spider-Man weekly also changed to more of a magazine format, with photo essays, reader comments, contests, and the like (as well as the obligatory reprints of Marvel US material).

The debut of the animated series Spider-Man and His Amazing Friends (1981–1983) on BBC One inspired the latest title change in October 1983.

Issues #607–#610 featured original Spider-Man stories by Mike Collins, Barry Kitson and Mark Farmer.

Initially the title reprinted Spider-Man stories from give-away issues in US newspapers — starting with the 1983 Spider-Man, Firestar and Iceman comic from the Denver Post — but shortly after these stories were replaced with tales for younger readers from the pages of the American title Spidey Super Stories, backed up by strips such as Wally the Wizard — renamed Willy the Wizard for the UK — and Fraggle Rock from the Marvel US children's imprint Star Comics.

Initially, the stories were simply reprints of the US comics based on the series, but eventually the title moved to all-new UK-originated stories, marking the first Marvel UK material featuring classic Marvel characters to be produced since early 1994.