Sycamore is a census-designated place (CDP) in Sequoyah County, Oklahoma, United States.

It is part of the Fort Smith, Arkansas-Oklahoma Metropolitan Statistical Area.

According to the United States Census Bureau, the CDP has a total area of 7.1 square miles (18 km2), all land.

The racial makeup of the CDP was 68.67% White, 22.67% Native American, and 8.67% from two or more races.

27.9% of all households were made up of individuals, and 13.1% had someone living alone who was 65 years of age or older.