[citation needed] The synaptojanin family comprises proteins that are key players in the synaptic vesicle recovery at the synapse.
The recovery of the vesicle is referred to as endocytosis and is important to reset the presynaptic cell with new neurotransmitter.
The third is a C-terminal domain that is rich in the amino acid proline and interacts with several proteins also involved in vesicle endocytosis.
The function of endophilin appears to be a binding partner for synaptojanin such that it can interact with other proteins and is involved in the initiation of shallow clathrin coated pits.
[5] Synaptojanin, through its interactions with a variety of proteins and molecules is thought to play a role in the development of nervous systems.
[6] Ephrin is a chemorepellent meaning that its interactions with proteins results in an inactivation or retraction of processes when referring to neuronal migration.
However the actual extension of the neurite involves the insertion of membrane lipids immediately behind the growth one.