The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles.

The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation.

[7] When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2.

When flipped inside out, i.e. N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called epimorphin.

This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts.