MSFP is measured after clamping the aortic root and the great veins at point of entry to right atrium.
It may also be estimated in vivo using a series of inspiratory holds when a patient is on a mechanical ventilator.
[4] It can be used to demonstrate effects of drugs on the venous tone while the circulating blood volume remains constant,[5] or to measure haemodynamic changes during haemorrhage.
An increase in mean systemic pressure is reflected in a shift of the vascular function curve to the right.
A decrease in mean systemic pressure is reflected in a shift of the vascular function curve to the left.