2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P, 4NXP, 4NXQ, 4NXR707421844ENSG00000156299ENSMUSG00000002489Q13009Q60610NM_003253NM_001145886NM_001145887NM_009384NP_001340617NP_001340618NP_001340619NP_001340620NP_001340621NP_001340622NP_001340623n/aRho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene.

TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities.

In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1,[7] Myc,[8] RAC1[9][10] and PPP1R9B.